MIGS Trends & Analysis Of IRIS Registry Data

MIGS Trends & Analysis Of IRIS Registry Data

May 03, 2021

Surgical treatment for glaucoma has experienced a dramatic change over the last decade. Trabeculectomy has been the main surgical procedure worldwide for nearly 50 times.

still, there's a growth in development of new new bias and surgical ways designed to lower intraocular pressure( IOP) in a less invasive fashion.

MIGS has come a generally used condensation in the glaucoma world. It stands for minimally invasive glaucoma surgery.

The thing of all glaucoma surgery is to lower eye pressure to help or reduce damage to the optical whim-whams.

MIGS is a state- of- the- art minimally invasive glaucoma surgery that uses bitsy instruments to grease small gash surgery. It provides a safer option to reduce eye pressure than conventional surgery, with the added benefits of a advanced success rate and faster recovery time.

The thing of MIGS procedures is to ameliorate fluid drainage out of the eye in cases with mild to moderate glaucoma, reducing elevated eye pressure that damages the optical whim-whams.

Clinical trials have shown that MIGS procedures achieve a significant drop in eye pressure over ages up to 24 months, along with a drop in tradition eye drop operation.

The use of minimally invasive glaucoma surgeries( MIGS) has increased markedly over the former 6 times in the United States, with a attendant( albeit lower) drop in traditional trabeculectomies and glaucoma drainage device( GDD) ways.

generally in the United States, the first- line remedy for glaucoma is administration of antiglaucoma eye drops or ray remedy; surgical interventions are reserved for more advanced or refractive glaucoma because they can be associated with a high threat of complications.

Implicit druthers to the current script are MIGS procedures, conjunctival- sparing ab interno drainage procedures, to give lowering of IOP, reduce the need for specifics and avoid the implicit pitfalls of surgical procedures.

How MIGS Work

These bias work in a many ways to drop IOP, but all attempt to do so with minimum dislocation of the scleral and conjunctiva. Microstents, similar as the iStent( Glaukos) device, are designed to bypass the juxtacanalicular trabecular network to increase the exodus through the trabecular network.

Others similar as Trabectome( NeoMedix), Kahook Dual Blade( New World Medical), and TRAB360( Sight Sciences) work via dwindling the exodus resistance by removing the trabecular network from within the anterior chamber.

Ab interno canaloplasty and the VISCO360( Sight Sciences) work by dilating Schlemm’s conduit. A alternate approach is adding the uveoscleral exodus by easing suprachoroidal pathways, as fulfilled by a stent( CyPassmicro-stent; Alcon).

Another device( XEN gel stent; Allergan) creates an peripheral subconjunctival drainage pathway. And, eventually, waterless product can be dropped by endocyclophotocoagulation( ECP). All are innovative, but the part of the MIGS bias isn't completely understood and raises questions.

Can they replace trabeculectomy to save sight and is their cost justified by their efficacity, safety, and duration of effect? Understanding the trends and patterns in the use of MIGS and who's entering them are important considerations in importing the cost and the limited substantiation of long- term safety and efficacity data.

Iris Registry Analysis

In light of collected data on the use of the colorful bias and the standard surgeries from 2013 to 2018, the primary study analysis sought to determine the periodic number of MIGS and standard procedures performed in the United States during the study course.

The secondary analysis was determination of the concurrent( same dates) and successional( different dates) MIGS and standard surgeries.

It has been reported that relating a2-fold increase in the use of MIGS procedures over the once 6 times in the United States that was accompanied by a gradational drop in traditional surgeries.

The periodic proportion of iStent procedures increased from 14 in 2013 to 40 over the 6- time period, and surpassed standard glaucoma surgeries by 2016 and reckoned for nearly half of all surgical glaucoma procedures by 2017.

Cypass and Xen only began to increase in frequence following United States Food and Drug Administration blessing and concurrence in 2016. The proportion of periodic goniotomy procedures also markedly increased since 2016.

The periodic rates of ECP and standard glaucoma procedures dropped during the 6- time study period. Regarding the analysis of the current and successional glaucoma surgeries, about one- third of eyes passed a concurrent procedure, with the preferred combination being ECP and iStent.

About two- thirds of eyes passed posterior procedures; that is, trabeculectomy and a GDD were the most frequently followed by another standard glaucoma surgery, but, she refocused out, when followed by a successional MIGS procedure, ECP and iStent were the most constantly chosen.


Recognition of the adding figures of iStent procedures and the concurrent drop in standard glaucoma surgeries didn't be in a vacuum and likely were associated with the preface of new antiglaucoma drug that can more control IOP, MIGS procedures that can be combined with phacoemulsification, and restrictions to remitments for traditional surgery and further MIGS procedures approved by the FDA and refunded.

specially, the lower decline in traditional glaucoma surgeries may indicate that trabeculectomy and GDD play a unique part in managing a lower niche of cases with advanced, fleetly progressive glaucoma demanding pronounced IOP reduction.

Another consideration is the demographic differences observed in association with the colorful glaucoma procedures. For illustration, advanced glaucoma frequence rate and inflexibility were seen in the Black population compared with Caucasian cases in the United States, which may explain why further standard glaucoma surgeries are used more frequently for Black cases.

Other reasons may be related to difference in the access to and application of eye care and lower comprehensive medical insurance among Black cases. According to data analysis, utmost MIGS procedures( particularly the iStent, Cypass, and ECP) are combined with phacoemulsification.

In the one- third of eyes that passed a concurrent glaucoma surgery, iStent and ECP were combined because of the cumulative benefits from different medium of action and the ease of performing them in combination, and lesser remitments for concerted procedures.

The findings outline the need for well- designed clinical trials demonstrating the long- term safety and effectiveness for both stage-alone and concerted MIGS ways.