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Development of An Innovative Accommodating Intraocular Lens By Adaptilens

Through an injectable, physiologically adaptive intraocular lens, Adaptilens is focused on making an accommodative intraocular lens available that mimics the natural human lens so that patients will have excellent near and distance vision without eyeglasses or contact lenses.

The biomimetic design of the Adaptilens most closely imitates the body’s natural lens. Adaptilens will allow the ciliary muscles inside the eye to change the shape of the lens so that the eye can accommodate naturally and focus clearly when viewing objects at near.

When the eye is focused on a distant object, the Adaptilens will return to its baseline elliptical shape to allow the eye to see clearly at distance.

The company has recently announced a $1.6 million seed funding led by Pillar VC with additional participation from Accanto Partners to fund the company’s development of an innovative accommodating intraocular lens with the aim of allowing patients to live their lives free of glasses and contact lenses.

At the first stage, the AdaptilensTM will be used for patients undergoing cataract surgery. According to the National Eye Institute, by 2050, the number of people with cataracts in the U.S. is expected to double from 24.4 million to approximately 50 million.

Every year, doctors in the U.S. perform about 4 million cataract surgeries, typically removing the cataractous lens and replacing it with a flat, monofocal lens that allows the patient to see clearly at distance or near, but not both.

As far as the truth is concerned, this doesn’t solve the whole problem and it leaves many patients still dependent on glasses which is a nuisance and risk for the patient. Adaptilens aims to solve this problem by developing a shape-changing, accommodating intraocular lens that allows patients to see clearly at multiple distances.

“Adaptilens is delighted to be partnering with Pillar and Accanto. We’re confident that with their strength and resources, we will be able to advance our technology rapidly and efficiently so that we can improve the quality of life for millions of people,” says Dr. Liane Clamen, Adaptilens’ Founder and CEO. “For decades, doctors have been replacing nature’s full, flexible lens with a flat, stiff lens. We are determined to provide a better solution by developing a flexible lens that lets the eye’s muscles of accommodation naturally change its shape, and allow people to see clearly at near, intermediate, and far distances.”

While this innovative lens will initially be used for patients with cataracts, the AdaptilensTM could also be used to correct the vision of patients with a variety of refractive errors. For example, the AdaptilensTM could be used for patients with presbyopia, which is the loss of near vision caused by decreased elasticity of the eye’s lens, typically occurring in middle age. Patients with presbyopia could achieve spectacle independence with the AdaptilensTM.

 

“The biggest challenge in solving age-related loss of near vision has been the difficulty of creating a lens that will respond to the eye’s natural signal to focus. We are developing a unique solution to maintain a person’s ability to see clearly and naturally at both distance and near by regaining intrinsic accommodation,” says Dr. Bonnie Henderson, Adaptilens Co-developer and Chair of its Scientific Advisory Board.

“We are thrilled to be partnering with the Adaptilens team to bring their innovative corrective eye technology to market,” says Jamie Goldstein, Founder and Partner at Pillar VC. “At Pillar, we look to support visionary technologies, which applies here in more ways than one.

The Adaptilens technology accomplishes this through their innovative intraocular lens that mimics the natural lens, something not achieved by current corrective eye surgeries.”

The inspiration for the AdaptilensTM came when Dr. Clamen was asked to write a textbook chapter about the history of the intraocular lens. After exhaustively researching artificial lenses, Dr. Clamen discovered that no one had succeeded in developing a lens that truly imitated the natural lens.

Seeing a huge opportunity for an unmet need among the visually impaired, Dr. Clamen partnered with renowned materials scientists to develop a new material that would allow for the development of a true, shape-changing, accommodating lens.

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